Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF558. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF558 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF558, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:8,580,484–8,581,056 | 251.3 kb | Distal (>10kb) Multiome | 535 | |
| chr19:8,591,781–8,593,224 | 239.8 kb | Distal (>10kb) Multiome | 389 | |
| chr19:8,609,061–8,609,913 | 222.8 kb | Distal (>10kb) Multiome | 432 | |
| chr19:8,832,015–8,833,117 | 431 bp | At TSS Multiome | 694 | |
| chr19:9,054,643–9,055,419 | 222.7 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the ZNF558 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.