This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for ZNF264. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF264 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF264, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:56,403,714–56,404,765 | 787.3 kb | Distal (>10kb) Multiome HiCAR | 745 | |
| chr19:57,191,186–57,191,993 | 33 bp | At TSS Multiome | 712 | |
| chr19:57,240,050–57,241,126 | 49.1 kb | Distal (>10kb) Multiome | 809 | |
| chr19:57,279,622–57,281,023 | 88.8 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:57,320,108–57,321,075 | 129.0 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 159.7 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 171.9 kb | Distal (>10kb) Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 198.4 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 219.6 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 243.9 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 286.1 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 296.3 kb | Distal (>10kb) Multiome | 483 |
Genomic view of the ZNF264 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.