TEAD2
TEA domain transcription factor 2 | ETF, TEF-4, TEF4

Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of DNA-templated transcription; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.20 Developmental clusters: GC1
Biological processes 35 terms
DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)TEAD-YAP complex (GO:0140552)chromatin (GO:0000785)disordered domain specific binding (GO:0097718)embryonic organ development (GO:0048568)hippo signaling (GO:0035329)hippo signaling (GO:0035329)hippo signaling (GO:0035329)mesenchyme development (GO:0060485)nervous system development (GO:0007399)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)protein binding (GO:0005515)protein-containing complex assembly (GO:0065003)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)sequence-specific double-stranded DNA binding (GO:1990837)transcription coactivator binding (GO:0001223)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)
Expression (TPM)
TEAD2 — as a Regulated Gene

TFs regulating TEAD2 0 TFs

Transcription factors with Perturb-seq knockdown data for TEAD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEAD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TEAD2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEAD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:49,064,668–49,065,682 296.4 kb Distal (>10kb) Multiome 226
chr19:49,071,761–49,072,903 289.5 kb Distal (>10kb) Multiome 278
chr19:49,084,646–49,086,115 276.2 kb Distal (>10kb) Multiome 1030
chr19:49,113,727–49,115,240 246.4 kb Distal (>10kb) Multiome 746
chr19:49,118,477–49,120,300 242.3 kb Distal (>10kb) Multiome 949
chr19:49,127,647–49,128,949 233.3 kb Distal (>10kb) Multiome 1000
chr19:49,129,106–49,129,678 231.9 kb Distal (>10kb) Multiome 197
chr19:49,132,975–49,134,197 228.0 kb Distal (>10kb) Multiome 179
chr19:49,142,781–49,143,252 218.4 kb Distal (>10kb) Multiome 299
chr19:49,145,727–49,146,720 215.3 kb Distal (>10kb) Multiome 511
chr19:49,148,659–49,150,947 210.9 kb Distal (>10kb) Multiome 917
chr19:49,151,539–49,152,548 209.5 kb Distal (>10kb) Multiome 497
chr19:49,157,555–49,158,336 203.7 kb Distal (>10kb) Multiome 599
chr19:49,210,032–49,211,225 150.9 kb Distal (>10kb) Multiome 366
chr19:49,337,997–49,340,482 22.3 kb Distal (>10kb) Multiome 612
chr19:49,361,283–49,362,837 75 bp At TSS Multiome 553
chr19:49,362,970–49,364,306 2.2 kb Proximal (<10kb) Multiome 616
chr19:49,403,611–49,404,247 42.4 kb Distal (>10kb) Multiome 305
chr19:49,432,343–49,432,785 71.0 kb Distal (>10kb) Multiome 103
chr19:49,436,149–49,436,821 75.0 kb Distal (>10kb) Multiome 248
chr19:49,441,067–49,441,861 80.0 kb Distal (>10kb) Multiome 223
chr19:49,442,072–49,444,054 81.5 kb Distal (>10kb) Multiome 914
chr19:49,451,347–49,452,239 90.4 kb Distal (>10kb) Multiome 764
chr19:49,452,723–49,453,850 91.9 kb Distal (>10kb) Multiome 847
chr19:49,476,063–49,476,551 114.9 kb Distal (>10kb) Multiome 244
chr19:49,487,027–49,488,279 125.9 kb Distal (>10kb) Multiome 964
chr19:49,495,613–49,496,661 134.7 kb Distal (>10kb) Multiome 919
chr19:49,500,403–49,501,353 139.2 kb Distal (>10kb) Multiome 405
chr19:49,512,565–49,513,700 151.6 kb Distal (>10kb) Multiome 655
chr19:49,527,651–49,528,221 166.4 kb Distal (>10kb) Multiome 354
chr19:49,533,232–49,534,476 172.6 kb Distal (>10kb) Multiome 534
chr19:49,555,629–49,557,180 194.7 kb Distal (>10kb) Multiome 294
chr19:49,580,125–49,580,813 219.1 kb Distal (>10kb) Multiome 848
chr19:49,589,601–49,594,008 232.0 kb Distal (>10kb) Multiome 994
chr19:49,638,063–49,638,728 276.8 kb Distal (>10kb) Multiome 237
chr19:49,639,671–49,642,787 278.9 kb Distal (>10kb) Multiome 1067

Genome Browser

Genomic view of the TEAD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:49,054,668 – 49,652,787
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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