Predicted to enable [phosphorylase] phosphatase activity; glycogen binding activity; and protein phosphatase 1 binding activity. Predicted to be involved in positive regulation of glycogen biosynthetic process. Predicted to be located in glycogen granule. Predicted to be part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP1R3E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R3E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R3E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,006,674–23,007,583 | 294.4 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 280.6 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 200.0 kb | Distal (>10kb) Multiome | 83 | |
| chr14:23,154,159–23,154,639 | 147.2 kb | Distal (>10kb) Multiome | 392 | |
| chr14:23,161,040–23,161,530 | 140.2 kb | Distal (>10kb) Multiome | 397 | |
| chr14:23,182,495–23,182,942 | 118.8 kb | Distal (>10kb) Multiome | 139 | |
| chr14:23,237,732–23,238,192 | 63.7 kb | Distal (>10kb) Multiome | 536 | |
| chr14:23,285,641–23,286,830 | 15.3 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 97 bp | At TSS Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 5.2 kb | Proximal (<10kb) Multiome | 871 | |
| chr14:23,320,558–23,322,196 | 19.6 kb | Distal (>10kb) Multiome | 1090 | |
| chr14:23,351,817–23,353,063 | 51.3 kb | Distal (>10kb) Multiome | 403 | |
| chr14:23,364,202–23,367,105 | 64.9 kb | Distal (>10kb) Multiome | 353 | |
| chr14:23,468,966–23,469,987 | 167.9 kb | Distal (>10kb) Multiome | 955 | |
| chr14:23,493,984–23,494,589 | 192.8 kb | Distal (>10kb) Multiome | 131 | |
| chr14:23,537,253–23,538,372 | 236.0 kb | Distal (>10kb) Multiome | 160 | |
| chr14:23,544,507–23,545,444 | 243.2 kb | Distal (>10kb) Multiome | 308 | |
| chr14:23,550,782–23,552,258 | 250.1 kb | Distal (>10kb) Multiome | 826 | |
| chr14:23,555,640–23,556,485 | 254.5 kb | Distal (>10kb) Multiome | 983 | |
| chr14:23,567,065–23,567,976 | 266.1 kb | Distal (>10kb) Multiome | 855 | |
| chr14:23,575,776–23,576,501 | 274.7 kb | Distal (>10kb) Multiome | 163 | |
| chr14:23,589,018–23,589,481 | 287.6 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the PPP1R3E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.