ZKSCAN5

zinc finger with KRAB and SCAN domains 5 | ZNF914, ZSCAN37, ZFP95

This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Member of: DE-5

Biological processes 11 terms

DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating ZKSCAN5 0 TFs

Transcription factors with Perturb-seq knockdown data for ZKSCAN5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZKSCAN5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZKSCAN5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZKSCAN5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:99,325,304–99,326,401	178.8 kb	Distal (>10kb) Multiome	858
chr7:99,373,955–99,375,619	129.1 kb	Distal (>10kb) Multiome	759
chr7:99,392,361–99,394,025	111.5 kb	Distal (>10kb) Multiome	486
chr7:99,407,975–99,409,432	95.9 kb	Distal (>10kb) Multiome	975
chr7:99,438,371–99,439,668	65.6 kb	Distal (>10kb) Multiome	881
chr7:99,465,842–99,466,381	38.5 kb	Distal (>10kb) Multiome	949
chr7:99,471,690–99,473,325	31.9 kb	Distal (>10kb) Multiome	861
chr7:99,499,759–99,500,629	4.4 kb	Proximal (<10kb) Multiome	809
chr7:99,504,224–99,505,507	108 bp	At TSS Multiome	881
chr7:99,557,927–99,559,319	54.0 kb	Distal (>10kb) Multiome	922
chr7:99,580,108–99,580,792	75.7 kb	Distal (>10kb) Multiome	296
chr7:99,616,474–99,617,353	112.2 kb	Distal (>10kb) Multiome	1043
chr7:99,693,257–99,693,867	188.9 kb	Distal (>10kb) Multiome	518

Genome Browser

Genomic view of the ZKSCAN5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.