This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020]
Transcription factors with Perturb-seq knockdown data for CEBPZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEBPZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEBPZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:36,965,735–36,967,324 | 265.0 kb | Distal (>10kb) Multiome | 1026 | |
| chr2:37,083,780–37,086,187 | 145.8 kb | Distal (>10kb) Multiome | 938 | |
| chr2:37,156,055–37,157,536 | 74.6 kb | Distal (>10kb) Multiome | 702 | |
| chr2:37,205,153–37,205,870 | 26.2 kb | Distal (>10kb) Multiome | 157 | |
| chr2:37,205,979–37,206,246 | 5.9 kb | Proximal (<10kb) | 140 | |
| chr2:37,231,272–37,232,043 | 11 bp | At TSS Multiome | 891 | |
| chr2:37,305,706–37,306,783 | 74.5 kb | Distal (>10kb) Multiome | 129 | |
| chr2:37,323,791–37,325,583 | 93.2 kb | Distal (>10kb) Multiome | 835 | |
| chr2:37,443,019–37,443,805 | 211.8 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the CEBPZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.