This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for ZNF449. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF449 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF449, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:135,051,315–135,052,574 | 292.6 kb | Distal (>10kb) Multiome | 523 | |
| chrX:135,097,570–135,099,197 | 245.9 kb | Distal (>10kb) Multiome | 354 | |
| chrX:135,342,871–135,343,075 | 1.7 kb | Proximal (<10kb) | 141 | |
| chrX:135,343,574–135,345,233 | 61 bp | At TSS Multiome | 657 | |
| chrX:135,421,575–135,422,695 | 77.1 kb | Distal (>10kb) Multiome | 332 | |
| chrX:135,520,416–135,522,245 | 175.8 kb | Distal (>10kb) Multiome | 678 |
Genomic view of the ZNF449 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.