The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for ZNF383. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF383 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF383, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:36,973,037–36,973,876 | 244.8 kb | Distal (>10kb) Multiome | 240 | |
| chr19:37,077,879–37,078,723 | 139.9 kb | Distal (>10kb) Multiome | 859 | |
| chr19:37,217,536–37,218,551 | 141 bp | At TSS Multiome | 914 | |
| chr19:37,228,119–37,228,291 | 9.9 kb | Proximal (<10kb) | 31 | |
| chr19:37,370,849–37,371,460 | 152.9 kb | Distal (>10kb) Multiome | 857 | |
| chr19:37,466,731–37,467,830 | 249.1 kb | Distal (>10kb) Multiome | 842 | |
| chr19:37,468,785–37,469,861 | 251.1 kb | Distal (>10kb) Multiome | 756 | |
| chr19:37,506,082–37,507,237 | 288.6 kb | Distal (>10kb) Multiome | 467 |
Genomic view of the ZNF383 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.