Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of cell population proliferation; and protein heterooligomerization. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF777. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF777 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF777, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:149,194,998–149,196,417 | 265.5 kb | Distal (>10kb) Multiome | 917 | |
| chr7:149,239,406–149,240,188 | 221.4 kb | Distal (>10kb) Multiome | 889 | |
| chr7:149,261,689–149,262,807 | 198.9 kb | Distal (>10kb) Multiome | 905 | |
| chr7:149,284,774–149,286,087 | 175.9 kb | Distal (>10kb) Multiome | 499 | |
| chr7:149,355,344–149,356,078 | 105.3 kb | Distal (>10kb) Multiome | 329 | |
| chr7:149,414,692–149,415,889 | 45.9 kb | Distal (>10kb) Multiome | 271 | |
| chr7:149,421,846–149,422,651 | 38.6 kb | Distal (>10kb) Multiome | 665 | |
| chr7:149,458,252–149,458,478 | 2.6 kb | Proximal (<10kb) | 30 | |
| chr7:149,459,399–149,461,328 | 390 bp | At TSS Multiome | 734 | |
| chr7:149,496,856–149,498,276 | 36.7 kb | Distal (>10kb) Multiome | 651 | |
| chr7:149,624,082–149,625,237 | 163.7 kb | Distal (>10kb) Multiome | 945 | |
| chr7:149,635,565–149,636,149 | 174.7 kb | Distal (>10kb) Multiome | 244 | |
| chr7:149,662,437–149,663,314 | 201.7 kb | Distal (>10kb) Multiome | 244 | |
| chr7:149,690,670–149,691,411 | 230.1 kb | Distal (>10kb) Multiome | 702 | |
| chr7:149,713,614–149,715,757 | 253.7 kb | Distal (>10kb) Multiome | 639 | |
| chr7:149,742,187–149,742,741 | 281.3 kb | Distal (>10kb) Multiome | 398 |
Genomic view of the ZNF777 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.