Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for AP1G2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP1G2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP1G2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,285,641–23,286,830 | 281.5 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 266.1 kb | Distal (>10kb) Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 261.0 kb | Distal (>10kb) Multiome | 871 | |
| chr14:23,320,558–23,322,196 | 246.6 kb | Distal (>10kb) Multiome | 1090 | |
| chr14:23,351,817–23,353,063 | 214.9 kb | Distal (>10kb) Multiome | 403 | |
| chr14:23,364,202–23,367,105 | 201.3 kb | Distal (>10kb) Multiome | 353 | |
| chr14:23,468,966–23,469,987 | 98.3 kb | Distal (>10kb) Multiome | 955 | |
| chr14:23,493,984–23,494,589 | 73.4 kb | Distal (>10kb) Multiome | 131 | |
| chr14:23,537,253–23,538,372 | 30.2 kb | Distal (>10kb) Multiome | 160 | |
| chr14:23,544,507–23,545,444 | 23.0 kb | Distal (>10kb) Multiome | 308 | |
| chr14:23,550,782–23,552,258 | 16.1 kb | Distal (>10kb) Multiome | 826 | |
| chr14:23,555,640–23,556,485 | 11.7 kb | Distal (>10kb) Multiome | 983 | |
| chr14:23,562,803–23,563,028 | 4.4 kb | Proximal (<10kb) | 238 | |
| chr14:23,567,065–23,567,976 | 87 bp | At TSS Multiome | 855 | |
| chr14:23,568,814–23,569,020 | 1.3 kb | Proximal (<10kb) | 202 | |
| chr14:23,575,776–23,576,501 | 8.5 kb | Proximal (<10kb) Multiome | 163 | |
| chr14:23,589,018–23,589,481 | 21.4 kb | Distal (>10kb) Multiome | 770 | |
| chr14:23,631,551–23,632,458 | 64.3 kb | Distal (>10kb) Multiome | 545 | |
| chr14:23,910,478–23,911,853 | 343.0 kb | Distal (>10kb) Multiome HiCAR | 310 | |
| chr14:23,953,479–23,954,293 | 386.0 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr14:24,051,239–24,052,875 | 484.1 kb | Distal (>10kb) Multiome HiCAR | 821 | |
| chr14:24,093,491–24,095,115 | 526.4 kb | Distal (>10kb) Multiome HiCAR | 990 | |
| chr14:24,113,681–24,115,917 | 547.2 kb | Distal (>10kb) Multiome HiCAR | 1166 |
Genomic view of the AP1G2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.