Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF140. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF140 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF140, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:132,828,453–132,829,499 | 251.8 kb | Distal (>10kb) Multiome | 930 | |
| chr12:132,887,106–132,888,371 | 193.2 kb | Distal (>10kb) Multiome | 840 | |
| chr12:132,907,962–132,909,233 | 172.2 kb | Distal (>10kb) Multiome | 481 | |
| chr12:132,955,400–132,956,621 | 124.6 kb | Distal (>10kb) Multiome | 715 | |
| chr12:132,986,063–132,986,840 | 94.5 kb | Distal (>10kb) Multiome | 840 | |
| chr12:133,036,951–133,037,971 | 43.4 kb | Distal (>10kb) Multiome | 973 | |
| chr12:133,079,789–133,081,303 | 468 bp | At TSS Multiome | 937 | |
| chr12:133,129,825–133,131,032 | 49.6 kb | Distal (>10kb) Multiome | 945 | |
| chr12:133,181,282–133,181,959 | 100.6 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the ZNF140 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.