This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for TCF7L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCF7L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCF7L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:84,855,538–84,856,452 | 277.4 kb | Distal (>10kb) Multiome | 137 | |
| chr2:84,879,622–84,881,453 | 252.4 kb | Distal (>10kb) Multiome | 434 | |
| chr2:84,881,776–84,882,617 | 251.1 kb | Distal (>10kb) Multiome | 438 | |
| chr2:84,904,641–84,908,593 | 226.0 kb | Distal (>10kb) Multiome | 1075 | |
| chr2:84,925,524–84,927,306 | 207.4 kb | Distal (>10kb) Multiome | 1034 | |
| chr2:84,957,753–84,958,825 | 175.2 kb | Distal (>10kb) Multiome | 500 | |
| chr2:84,959,740–84,960,486 | 173.3 kb | Distal (>10kb) Multiome | 381 | |
| chr2:84,970,310–84,972,229 | 162.4 kb | Distal (>10kb) Multiome | 809 | |
| chr2:84,986,815–84,987,471 | 146.3 kb | Distal (>10kb) Multiome | 29 | |
| chr2:85,033,412–85,033,982 | 99.8 kb | Distal (>10kb) Multiome | 100 | |
| chr2:85,066,689–85,067,387 | 66.3 kb | Distal (>10kb) Multiome | 352 | |
| chr2:85,119,847–85,120,292 | 13.3 kb | Distal (>10kb) Multiome | 127 | |
| chr2:85,132,493–85,135,747 | 161 bp | At TSS Multiome | 660 | |
| chr2:85,174,805–85,176,312 | 42.2 kb | Distal (>10kb) Multiome | 399 | |
| chr2:85,178,933–85,179,785 | 45.9 kb | Distal (>10kb) Multiome | 95 | |
| chr2:85,237,653–85,238,609 | 104.7 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr2:85,255,366–85,256,615 | 122.8 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr2:85,285,331–85,285,778 | 152.2 kb | Distal (>10kb) Multiome HiCAR | 463 | |
| chr2:85,327,503–85,328,538 | 194.7 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:85,354,014–85,355,224 | 221.2 kb | Distal (>10kb) Multiome | 962 | |
| chr2:85,413,587–85,414,333 | 280.4 kb | Distal (>10kb) Multiome | 351 | |
| chr2:85,418,133–85,419,210 | 285.2 kb | Distal (>10kb) Multiome | 885 | |
| chr2:85,420,473–85,421,406 | 287.5 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the TCF7L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.