Enables ubiquitin protein ligase binding activity. Involved in negative regulation of osteoclast differentiation; negative regulation of signal transduction; and regulation of DNA-templated transcription. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ZNF675. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF675 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF675, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:21,851,477–21,852,502 | 1835.2 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr19:23,074,842–23,075,882 | 611.9 kb | Distal (>10kb) Multiome HiCAR | 399 | |
| chr19:23,394,943–23,396,090 | 291.7 kb | Distal (>10kb) Multiome HiCAR | 575 | |
| chr19:23,415,164–23,416,387 | 271.3 kb | Distal (>10kb) Multiome | 222 | |
| chr19:23,686,411–23,687,441 | 67 bp | At TSS Multiome | 490 | |
| chr19:23,718,765–23,719,251 | 31.7 kb | Distal (>10kb) Multiome | 11 | |
| chr19:23,723,949–23,724,608 | 36.9 kb | Distal (>10kb) Multiome | 69 | |
| chr19:23,758,246–23,759,135 | 71.7 kb | Distal (>10kb) Multiome | 349 | |
| chr19:23,762,593–23,763,893 | 75.8 kb | Distal (>10kb) Multiome | 429 |
Genomic view of the ZNF675 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.