This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for ZNF136. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF136 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF136, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:12,139,827–12,140,825 | 22.8 kb | Distal (>10kb) Multiome | 594 | |
| chr19:12,156,210–12,156,965 | 6.3 kb | Proximal (<10kb) Multiome | 638 | |
| chr19:12,162,692–12,163,608 | 28 bp | At TSS Multiome | 697 | |
| chr19:12,365,585–12,366,054 | 202.7 kb | Distal (>10kb) Multiome | 577 | |
| chr19:12,400,090–12,401,657 | 238.2 kb | Distal (>10kb) Multiome | 671 | |
| chr19:12,440,217–12,441,483 | 278.0 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the ZNF136 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.