Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of sensory perception of pain. Located in nucleus. Implicated in Marsili syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFHX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFHX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFHX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,285,641–23,286,830 | 265.5 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 250.1 kb | Distal (>10kb) Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 245.0 kb | Distal (>10kb) Multiome | 871 | |
| chr14:23,320,558–23,322,196 | 230.5 kb | Distal (>10kb) Multiome | 1090 | |
| chr14:23,351,817–23,353,063 | 198.9 kb | Distal (>10kb) Multiome | 403 | |
| chr14:23,364,202–23,367,105 | 185.3 kb | Distal (>10kb) Multiome | 353 | |
| chr14:23,468,966–23,469,987 | 82.3 kb | Distal (>10kb) Multiome | 955 | |
| chr14:23,493,984–23,494,589 | 57.4 kb | Distal (>10kb) Multiome HiCAR | 131 | |
| chr14:23,537,253–23,538,372 | 14.2 kb | Distal (>10kb) Multiome | 160 | |
| chr14:23,544,507–23,545,444 | 7.0 kb | Proximal (<10kb) Multiome | 308 | |
| chr14:23,550,782–23,552,258 | 45 bp | At TSS Multiome | 826 | |
| chr14:23,555,640–23,556,485 | 4.3 kb | Proximal (<10kb) Multiome | 983 | |
| chr14:23,567,065–23,567,976 | 15.9 kb | Distal (>10kb) Multiome | 855 | |
| chr14:23,575,776–23,576,501 | 24.5 kb | Distal (>10kb) Multiome | 163 | |
| chr14:23,589,018–23,589,481 | 37.4 kb | Distal (>10kb) Multiome | 770 | |
| chr14:23,631,551–23,632,458 | 80.4 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the ZFHX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.