This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for GATA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,486,731–128,487,080 | 835 bp | At TSS | 273 | |
| chr3:128,487,682–128,488,679 | at TSS | At TSS | 710 | |
| chr3:128,488,798–128,489,787 | 882 bp | At TSS | 515 | |
| chr3:128,489,907–128,490,591 | 2.0 kb | Proximal (<10kb) | 413 | |
| chr3:128,492,255–128,493,190 | 4.3 kb | Proximal (<10kb) | 270 | |
| chr3:128,497,309–128,498,144 | 9.4 kb | Proximal (<10kb) | 464 |
Genomic view of the GATA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.