This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for DMTF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMTF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMTF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:86,964,698–86,966,215 | 187.3 kb | Distal (>10kb) Multiome | 164 | |
| chr7:87,058,811–87,060,346 | 92.7 kb | Distal (>10kb) Multiome | 675 | |
| chr7:87,128,891–87,130,142 | 23.1 kb | Distal (>10kb) Multiome | 290 | |
| chr7:87,148,446–87,148,641 | 3.8 kb | Proximal (<10kb) | 111 | |
| chr7:87,151,812–87,153,325 | 77 bp | At TSS Multiome | 1045 | |
| chr7:87,154,462–87,155,145 | 2.1 kb | Proximal (<10kb) | 113 | |
| chr7:87,218,879–87,221,122 | 68.1 kb | Distal (>10kb) Multiome | 908 | |
| chr7:87,344,909–87,346,229 | 193.2 kb | Distal (>10kb) Multiome | 838 |
Genomic view of the DMTF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.