This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for ZNF33B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF33B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF33B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:42,551,804–42,553,654 | 85.7 kb | Distal (>10kb) Multiome | 691 | |
| chr10:42,637,674–42,639,023 | 178 bp | At TSS Multiome | 972 | |
| chr10:42,752,966–42,756,016 | 114.7 kb | Distal (>10kb) Multiome | 466 | |
| chr10:42,782,066–42,783,465 | 144.2 kb | Distal (>10kb) Multiome | 1124 | |
| chr10:42,866,108–42,867,222 | 228.3 kb | Distal (>10kb) Multiome | 204 | |
| chr10:42,932,398–42,934,239 | 294.3 kb | Distal (>10kb) Multiome | 252 |
Genomic view of the ZNF33B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.