This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for MYCN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYCN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYCN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:15,938,297–15,944,152 | 233 bp | At TSS Multiome | 739 | |
| chr2:15,958,030–15,959,112 | 17.9 kb | Distal (>10kb) Multiome HiCAR | 159 | |
| chr2:15,980,336–15,981,071 | 40.1 kb | Distal (>10kb) Multiome | 180 | |
| chr2:16,104,408–16,106,306 | 165.3 kb | Distal (>10kb) Multiome HiCAR | 426 | |
| chr2:16,507,459–16,508,899 | 567.8 kb | Distal (>10kb) Multiome HiCAR | 387 |
Genomic view of the MYCN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.