This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for FLI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:128,685,039–128,685,575 | 7.4 kb | Proximal (<10kb) | 117 | |
| chr11:128,686,022–128,687,233 | 5.7 kb | Proximal (<10kb) | 161 | |
| chr11:128,687,395–128,687,871 | 5.1 kb | Proximal (<10kb) | 88 | |
| chr11:128,689,204–128,690,627 | 2.4 kb | Proximal (<10kb) | 121 | |
| chr11:128,691,865–128,692,551 | 429 bp | At TSS | 141 | |
| chr11:128,692,776–128,695,514 | at TSS | At TSS | 466 |
Genomic view of the FLI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.