ZNF101

zinc finger protein 101 | DKFZp570I0164, HZF12

Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Nov 2010]

Developmental clusters: GC5

Biological processes 7 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF101 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF101. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF101 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF101

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF101, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:19,384,944–19,386,424	283.2 kb	Distal (>10kb) Multiome	788
chr19:19,405,072–19,406,890	263.2 kb	Distal (>10kb) Multiome	1014
chr19:19,461,886–19,462,726	206.5 kb	Distal (>10kb) Multiome	345
chr19:19,515,735–19,516,510	152.7 kb	Distal (>10kb) Multiome	824
chr19:19,532,119–19,532,674	136.5 kb	Distal (>10kb) Multiome	405
chr19:19,538,087–19,538,726	130.5 kb	Distal (>10kb) Multiome	255
chr19:19,539,681–19,541,846	127.5 kb	Distal (>10kb) Multiome	352
chr19:19,575,151–19,576,000	93.3 kb	Distal (>10kb) Multiome	128
chr19:19,618,285–19,619,315	50.1 kb	Distal (>10kb) Multiome	414
chr19:19,627,596–19,629,138	40.4 kb	Distal (>10kb) Multiome	543
chr19:19,637,337–19,638,344	31.2 kb	Distal (>10kb) Multiome	153
chr19:19,643,155–19,644,142	25.1 kb	Distal (>10kb) Multiome	595
chr19:19,662,031–19,662,351	6.5 kb	Proximal (<10kb)	133
chr19:19,663,091–19,664,414	4.9 kb	Proximal (<10kb) Multiome	848
chr19:19,668,196–19,669,404	110 bp	At TSS Multiome	778
chr19:19,669,932–19,670,337	1.1 kb	Proximal (<10kb)	95
chr19:19,732,628–19,733,489	64.3 kb	Distal (>10kb) Multiome	701
chr19:19,775,960–19,777,126	107.7 kb	Distal (>10kb) Multiome	738
chr19:19,860,773–19,861,447	192.4 kb	Distal (>10kb) Multiome HiCAR	112
chr19:19,865,643–19,866,347	197.0 kb	Distal (>10kb) Multiome HiCAR	685
chr19:19,866,439–19,867,170	198.1 kb	Distal (>10kb) Multiome HiCAR	306
chr19:19,900,670–19,901,891	232.1 kb	Distal (>10kb) Multiome HiCAR	405

Genome Browser

Genomic view of the ZNF101 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.