TEAD3

TEA domain transcription factor 3 | ETFR-1, TEF-5, TEAD5

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

Biological processes 23 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)asymmetric neuroblast division (GO:0055059)chromatin (GO:0000785)embryonic organ development (GO:0048568)female pregnancy (GO:0007565)hippo signaling (GO:0035329)hippo signaling (GO:0035329)hippo signaling (GO:0035329)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating TEAD3 0 TFs

Transcription factors with Perturb-seq knockdown data for TEAD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEAD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TEAD3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEAD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:35,213,536–35,214,675	283.0 kb	Distal (>10kb) Multiome	310
chr6:35,258,904–35,260,476	237.4 kb	Distal (>10kb) Multiome	1142
chr6:35,297,619–35,298,109	199.3 kb	Distal (>10kb) Multiome	765
chr6:35,317,884–35,318,871	178.6 kb	Distal (>10kb) Multiome	727
chr6:35,342,126–35,343,068	154.6 kb	Distal (>10kb) Multiome	831
chr6:35,451,927–35,453,018	44.8 kb	Distal (>10kb) Multiome	799
chr6:35,467,935–35,469,331	28.7 kb	Distal (>10kb) Multiome	1091
chr6:35,485,138–35,486,890	10.6 kb	Distal (>10kb) Multiome	400
chr6:35,490,011–35,490,813	6.7 kb	Proximal (<10kb) Multiome	310
chr6:35,491,080–35,492,487	4.6 kb	Proximal (<10kb)	197
chr6:35,495,972–35,498,486	31 bp	At TSS Multiome	939
chr6:35,522,668–35,523,295	25.9 kb	Distal (>10kb) Multiome	419
chr6:35,687,984–35,689,594	192.0 kb	Distal (>10kb) Multiome	968
chr6:35,727,435–35,728,457	230.9 kb	Distal (>10kb) Multiome	812
chr6:35,731,025–35,732,630	234.6 kb	Distal (>10kb) Multiome HiCAR	1000
chr6:35,764,004–35,765,052	267.5 kb	Distal (>10kb) Multiome	254
chr6:35,776,412–35,776,992	279.6 kb	Distal (>10kb) Multiome	410

Genome Browser

Genomic view of the TEAD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.