This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for GATA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:7,787,377–7,789,109 | 257.3 kb | Distal (>10kb) Multiome | 843 | |
| chr10:7,818,056–7,819,396 | 226.9 kb | Distal (>10kb) Multiome | 897 | |
| chr10:8,036,042–8,036,183 | 9.2 kb | Proximal (<10kb) | 58 | |
| chr10:8,036,304–8,036,433 | 8.9 kb | Proximal (<10kb) | 21 | |
| chr10:8,037,991–8,038,513 | 6.9 kb | Proximal (<10kb) | 54 | |
| chr10:8,043,070–8,044,042 | 1.3 kb | Proximal (<10kb) | 183 | |
| chr10:8,044,436–8,045,614 | at TSS | At TSS | 246 | |
| chr10:8,046,840–8,047,373 | 1.5 kb | Proximal (<10kb) | 84 | |
| chr10:8,047,568–8,048,598 | 2.7 kb | Proximal (<10kb) Multiome | 190 | |
| chr10:8,049,343–8,052,545 | 4.5 kb | Proximal (<10kb) Multiome | 796 | |
| chr10:8,053,150–8,055,390 | 8.1 kb | Proximal (<10kb) Multiome | 590 | |
| chr10:8,055,536–8,056,709 | 1.9 kb | Proximal (<10kb) | 272 | |
| chr10:8,057,550–8,057,976 | 3.9 kb | Proximal (<10kb) | 92 | |
| chr10:8,058,367–8,058,884 | 4.8 kb | Proximal (<10kb) | 115 | |
| chr10:8,061,155–8,061,606 | 7.6 kb | Proximal (<10kb) | 120 | |
| chr10:8,063,517–8,063,831 | 9.9 kb | Proximal (<10kb) | 81 | |
| chr10:8,071,272–8,072,513 | 26.6 kb | Distal (>10kb) Multiome | 160 | |
| chr10:8,406,922–8,408,220 | 362.4 kb | Distal (>10kb) Multiome HiCAR | 302 |
Genomic view of the GATA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.