The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GTF3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:27,170,635–27,172,412 | 252.7 kb | Distal (>10kb) Multiome | 737 | |
| chr13:27,251,189–27,251,961 | 173.2 kb | Distal (>10kb) Multiome | 890 | |
| chr13:27,270,323–27,271,477 | 153.7 kb | Distal (>10kb) Multiome | 687 | |
| chr13:27,361,835–27,362,747 | 62.4 kb | Distal (>10kb) Multiome | 476 | |
| chr13:27,424,036–27,425,195 | 23 bp | At TSS Multiome | 868 | |
| chr13:27,425,951–27,426,134 | 1.3 kb | Proximal (<10kb) | 432 | |
| chr13:27,449,915–27,451,120 | 25.7 kb | Distal (>10kb) Multiome | 928 | |
| chr13:27,619,862–27,622,369 | 197.2 kb | Distal (>10kb) Multiome | 1017 | |
| chr13:27,826,355–27,826,879 | 402.0 kb | Distal (>10kb) Multiome HiCAR | 341 |
Genomic view of the GTF3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.