Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF608. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF608 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF608, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:124,277,608–124,278,921 | 468.5 kb | Distal (>10kb) Multiome HiCAR | 253 | |
| chr5:124,580,889–124,582,318 | 165.4 kb | Distal (>10kb) Multiome | 537 | |
| chr5:124,628,764–124,630,157 | 117.2 kb | Distal (>10kb) Multiome | 604 | |
| chr5:124,651,333–124,652,287 | 94.8 kb | Distal (>10kb) Multiome | 722 | |
| chr5:124,735,238–124,735,792 | 11.2 kb | Distal (>10kb) Multiome | 371 | |
| chr5:124,737,295–124,737,976 | 8.7 kb | Proximal (<10kb) | 118 | |
| chr5:124,738,504–124,739,811 | 7.4 kb | Proximal (<10kb) Multiome | 417 | |
| chr5:124,742,193–124,742,482 | 4.2 kb | Proximal (<10kb) | 266 | |
| chr5:124,746,548–124,747,878 | 812 bp | At TSS Multiome | 462 | |
| chr5:124,748,456–124,749,642 | 2.4 kb | Proximal (<10kb) Multiome | 554 | |
| chr5:124,750,721–124,751,870 | 4.1 kb | Proximal (<10kb) | 174 | |
| chr5:124,752,974–124,753,601 | 6.6 kb | Proximal (<10kb) Multiome | 193 | |
| chr5:124,776,698–124,777,163 | 30.3 kb | Distal (>10kb) Multiome | 47 | |
| chr5:124,908,631–124,909,975 | 162.4 kb | Distal (>10kb) Multiome HiCAR | 518 | |
| chr5:124,963,150–124,963,879 | 216.8 kb | Distal (>10kb) Multiome | 289 | |
| chr5:124,970,326–124,970,890 | 224.0 kb | Distal (>10kb) Multiome | 36 | |
| chr5:124,980,287–124,980,927 | 234.1 kb | Distal (>10kb) Multiome | 262 | |
| chr5:125,026,938–125,027,771 | 280.9 kb | Distal (>10kb) Multiome | 374 | |
| chr5:125,668,838–125,669,767 | 922.5 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr5:125,673,192–125,673,859 | 927.0 kb | Distal (>10kb) Multiome HiCAR | 101 |
Genomic view of the ZNF608 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.