chr6:167,146,776–167,147,442

chr6 : 167,146,776 – 167,147,442

666 bp 130 TFs 6 linked genes

This 666 bp open chromatin element is linked to 6 target genes and is bound by 130 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000291286		393 bp	At TSS	Proximity
HPAT5		81.1 kb	Distal	Multiome
ENSG00000285730		147.6 kb	Distal	Multiome
CEP43		147.8 kb	Distal	Multiome
ENSG00000227598		148.1 kb	Distal	Multiome
RNASET2		190.6 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

130 transcription factors

ChIP WTC11 ENCFF556XTF 445 bp overlap

ChIP prostate_P27 GSE130408.AR.prostate_P27 169 bp overlap

ASCL1 2 datasets

Motif DE_12h DE_12h-ASCL1_MA1631.2 9 bp overlap

Motif ES_0h ES_0h-ASCL1_MA1631.2 9 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 660 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 648 bp overlap

ATF2 2 datasets

ChIP H1 ENCFF295GZO 460 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 549 bp overlap

ChIP OCI-Ly1 GSE29282.BCL6.OCI-Ly1 223 bp overlap

BCOR 4 datasets

ChIP WA01 GSE104690.BCOR.WA01 461 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 184 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 586 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 552 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 666 bp overlap

ChIP WA01 ENCSR000EBT.CHD2.WA01 139 bp overlap

ChIP RH5 GSE155861.CHD4.RH5 335 bp overlap

CHD7 2 datasets

ChIP WA01 ENCSR000AVA.CHD7.WA01 182 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 312 bp overlap

CREB1 1 dataset

ChIP WA01 ENCSR000BSN.CREB1.WA01 169 bp overlap

CTBP2 2 datasets

ChIP H1 ENCFF329MAX 567 bp overlap

ChIP WA01 ENCSR000EUO.CTBP2.WA01 507 bp overlap

ChIP U-87MG_GBM GSE99171.E2F1.U-87MG_GBM 114 bp overlap

E2F6 2 datasets

ChIP H1 ENCFF785DWK 451 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 663 bp overlap

EBF1 2 datasets

Motif DE_12h DE_12h-EBF1_MA0154.5 11 bp overlap

Motif ES_0h ES_0h-EBF1_MA0154.5 11 bp overlap

ChIP HepG2 ENCFF347CCA 367 bp overlap

EP300 2 datasets

ChIP H1 ENCFF927IYK 297 bp overlap

ChIP WA01 ENCSR000BKK.EP300.WA01 324 bp overlap

ERF::NHLH1 1 dataset

Motif DE_12h DE_12h-ERFNHLH1_MA1938.2 16 bp overlap

ESR1 4 datasets

ChIP MCF-7_PaPE-1 GSE93510.ESR1.MCF-7_PaPE-1 361 bp overlap

ChIP T-47D_D538G_E2 GSE148277.ESR1.T-47D_D538G_E2 469 bp overlap

ChIP T-47D_Y537S GSE148277.ESR1.T-47D_Y537S 320 bp overlap

ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 286 bp overlap

ChIP WTC11 ENCFF812SCD 350 bp overlap

EZH2 6 datasets

ChIP Hep-G2 ENCSR000ARI.EZH2.Hep-G2 349 bp overlap

ChIP PC-9 ENCSR793USK.EZH2.PC-9 666 bp overlap

ChIP RCH-ACV GSE135024.EZH2.RCH-ACV 398 bp overlap

ChIP T98G GSE112240.EZH2.T98G 341 bp overlap

ChIP WA01 ENCSR000ASY.EZH2.WA01 392 bp overlap

ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 246 bp overlap

EZH2_phosphoT487 1 dataset

ChIP neuron_bipolar_doxy_4d ENCSR886KKK.EZH2_phosphoT487.neuron_bipolar_doxy_4d 565 bp overlap

Ebf4 2 datasets

Motif DE_12h DE_12h-Ebf4_MA2122.1 11 bp overlap

Motif ES_0h ES_0h-Ebf4_MA2122.1 11 bp overlap

FIGLA 2 datasets

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

Motif ES_0h ES_0h-FIGLA_MA0820.2 6 bp overlap

FIP1L1 1 dataset

ChIP Hep-G2 ENCSR313VZG.FIP1L1.Hep-G2 212 bp overlap

FOXD2 1 dataset

Motif DE_12h DE_12h-FOXD2_MA0847.4 11 bp overlap

FOXP1 1 dataset

ChIP WTC11 ENCFF338WGC 445 bp overlap

FOXP4 1 dataset

ChIP WTC11 ENCFF708TAF 377 bp overlap

GATA6 1 dataset

ChIP DE_D1 S41-DE-d1-GATA6-exp2 292 bp overlap

Motif ES_0h ES_0h-GLI3_MA1491.3 15 bp overlap

GLIS1 1 dataset

Motif ES_0h ES_0h-GLIS1_MA0735.2 15 bp overlap

GLIS2 1 dataset

Motif ES_0h ES_0h-GLIS2_MA0736.1 14 bp overlap

GLIS3 2 datasets

Motif ES_0h ES_0h-GLIS3_MA0737.1 14 bp overlap

ChIP H9_plus GSE109562.GLIS3.H9_plus 666 bp overlap

Motif ES_0h ES_0h-Gli1_MA1990.2 10 bp overlap

Motif ES_0h ES_0h-Gli2_MA0734.4 9 bp overlap

HDAC2 4 datasets

ChIP H1 ENCFF353UJQ 632 bp overlap

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 189 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 228 bp overlap

Motif DE_12h DE_12h-IRF7_MA0772.2 13 bp overlap

Motif DE_12h DE_12h-Irf1_MA0050.4 11 bp overlap

JARID2 2 datasets

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 195 bp overlap

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 462 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 638 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 630 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 559 bp overlap

KDM4A 4 datasets

ChIP WA01 ENCSR000AVC.KDM4A.WA01 141 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 171 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 155 bp overlap

ChIP hiPSC_IID12 GSE106870.KDM4A.hiPSC_IID12 175 bp overlap

Motif ES_0h ES_0h-KLF9_MA1107.3 11 bp overlap

KMT2A 1 dataset

ChIP RCH-ACV GSE83671.KMT2A.RCH-ACV 647 bp overlap

LIN54 1 dataset

Motif DE_12h DE_12h-LIN54_MA0619.2 7 bp overlap

ChIP H1 ENCFF914VQY 330 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 297 bp overlap

ChIP WA01 ENCSR000EUP.MAX.WA01 559 bp overlap

ChIP WTC11 ENCFF223QFY 492 bp overlap

MEF2A 1 dataset

Motif DE_12h DE_12h-MEF2A_MA0052.5 10 bp overlap

MEF2C 1 dataset

Motif DE_12h DE_12h-MEF2C_MA0497.2 11 bp overlap

MEIS2 1 dataset

Motif DE_12h DE_12h-MEIS2_MA1640.2 9 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 470 bp overlap

Motif ES_0h ES_0h-MYB_MA0100.4 6 bp overlap

NANOG 8 datasets

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 650 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 227 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 259 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 485 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 559 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 384 bp overlap

NELFE 1 dataset

ChIP K-562_HS GSE112379.NELFE.K-562_HS 145 bp overlap

NFATC3 1 dataset

Motif DE_12h DE_12h-NFATC3_MA0625.3 6 bp overlap

NIPBL 1 dataset

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 296 bp overlap

NR2F1 1 dataset

Motif ES_0h ES_0h-NR2F1_MA0017.3 12 bp overlap

Nfatc1 1 dataset

Motif DE_12h DE_12h-Nfatc1_MA0624.3 6 bp overlap

Nfatc2 1 dataset

Motif DE_12h DE_12h-Nfatc2_MA0152.3 8 bp overlap

Nr1h3::Rxra 2 datasets

Motif DE_12h DE_12h-Nr1h3Rxra_MA0494.2 16 bp overlap

Motif ES_0h ES_0h-Nr1h3Rxra_MA0494.2 16 bp overlap

PCGF1 1 dataset

ChIP WA01 GSE104690.PCGF1.WA01 666 bp overlap

ChIP T-47D_PROG GSE68355.PGR.T-47D_PROG 201 bp overlap

POLR2A 1 dataset

ChIP H1 ENCFF566JSR 271 bp overlap

POU1F1 1 dataset

Motif DE_12h DE_12h-POU1F1_MA0784.3 14 bp overlap

POU2F2 1 dataset

Motif DE_12h DE_12h-POU2F2_MA0507.3 13 bp overlap

POU3F1 1 dataset

Motif DE_12h DE_12h-POU3F1_MA0786.2 10 bp overlap

POU3F2 1 dataset

Motif DE_12h DE_12h-POU3F2_MA0787.1 12 bp overlap

POU3F3 1 dataset

Motif DE_12h DE_12h-POU3F3_MA0788.1 13 bp overlap

POU5F1 6 datasets

ChIP BG03 GSE21614.POU5F1.BG03 235 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 525 bp overlap

ChIP H1 ENCFF698ZAP 205 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 666 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 328 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 164 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 391 bp overlap

PRDM14 1 dataset

ChIP hESC GSE138674.PRDM14.hESC 592 bp overlap

PTBP1 1 dataset

ChIP Hep-G2 ENCSR156APP.PTBP1.Hep-G2 127 bp overlap

Prdm5 1 dataset

Motif DE_12h DE_12h-Prdm5_MA1999.2 11 bp overlap

RBBP5 3 datasets

ChIP H1 ENCFF905HFL 611 bp overlap

ChIP H1 ENCFF905HFL 396 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 398 bp overlap

REST 3 datasets

ChIP H1 ENCFF429RUE 245 bp overlap

ChIP hiPSC_IB12 GSE106870.REST.hiPSC_IB12 168 bp overlap

ChIP neural ENCSR000BTV.REST.neural 145 bp overlap

RNF2 4 datasets

ChIP WA01 GSE104690.RNF2.WA01 239 bp overlap

ChIP WA01 ENCSR784VUY.RNF2.WA01 305 bp overlap

ChIP WA09 GSE105028.RNF2.WA09 559 bp overlap

ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 485 bp overlap

RUNX1 1 dataset

ChIP epididymis_HEE GSE109061.RUNX1.epididymis_HEE 304 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 666 bp overlap

SALL3 1 dataset

ChIP hiPSC GSE104863.SALL3.hiPSC 298 bp overlap

SIN3A 2 datasets

ChIP H1 ENCFF896IJG 301 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 172 bp overlap

SMAD2 3 datasets

ChIP hESC GSE29422.SMAD2.hESC 116 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 499 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 555 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 347 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 404 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 429 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 666 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 407 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 666 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 620 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 476 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 497 bp overlap

SMAD3 5 datasets

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 528 bp overlap

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 349 bp overlap

ChIP WTC11 ENCFF815YYQ 357 bp overlap

ChIP hESC GSE29422.SMAD3.hESC 175 bp overlap

ChIP hESC GSE29422.SMAD3.hESC 365 bp overlap

SMARCA4 2 datasets

ChIP hiPSC GSE124903.SMARCA4.hiPSC 438 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 619 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 285 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 460 bp overlap

SMARCC1 3 datasets

ChIP ESC S25-ESC-d0-BAF155-exp1 327 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 317 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 392 bp overlap

SNAI1 2 datasets

Motif DE_12h DE_12h-SNAI1_MA1558.2 7 bp overlap

Motif ES_0h ES_0h-SNAI1_MA1558.2 7 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 435 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 313 bp overlap

Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap

SRSF3 1 dataset

ChIP K-562 GSE120104.SRSF3.K-562 166 bp overlap

STAT1::STAT2 1 dataset

Motif ES_0h ES_0h-STAT1STAT2_MA0517.2 13 bp overlap

STAT3 3 datasets

ChIP T-47D_JC4757 GSE126004.STAT3.T-47D_JC4757 234 bp overlap

ChIP T-47D_JC5054 GSE126004.STAT3.T-47D_JC5054 304 bp overlap

ChIP T-47D_JC5062 GSE126004.STAT3.T-47D_JC5062 294 bp overlap

SUZ12 1 dataset

ChIP hiPSC_WT GSE124903.SUZ12.hiPSC_WT 415 bp overlap

Sox11 1 dataset

Motif ES_0h ES_0h-Sox11_MA0869.3 8 bp overlap

TAF1 2 datasets

ChIP H1 ENCFF478SZO 485 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 369 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 164 bp overlap

TCF12 4 datasets

Motif DE_12h DE_12h-TCF12_MA1648.2 7 bp overlap

Motif ES_0h ES_0h-TCF12_MA1648.2 7 bp overlap

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 404 bp overlap

TCF3 2 datasets

Motif DE_12h DE_12h-TCF3_MA0522.4 7 bp overlap

Motif ES_0h ES_0h-TCF3_MA0522.4 7 bp overlap

Motif DE_12h DE_12h-TCF4_MA0830.3 8 bp overlap

TEAD1 2 datasets

ChIP WTC11 ENCFF502QUV 405 bp overlap

ChIP pancreas_12D ERP008682.TEAD1.pancreas_12D 193 bp overlap

TEAD4 4 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 638 bp overlap

ChIP H1 ENCFF778PAX 245 bp overlap

ChIP H1 ENCFF778PAX 245 bp overlap

ChIP hESC GSE99202.TEAD4.hESC 360 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 521 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 635 bp overlap

Motif ES_0h ES_0h-THRA_MA1969.2 18 bp overlap

TRIM25 1 dataset

ChIP MDA-MB-231 GSE79588.TRIM25.MDA-MB-231 212 bp overlap

TRIM28 3 datasets

ChIP AF22 GSE84259.TRIM28.AF22 419 bp overlap

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 324 bp overlap

ChIP hESC GSE115387.TRIM28.hESC 280 bp overlap

USF1 3 datasets

ChIP H1 ENCFF090WVU 241 bp overlap

ChIP WA01 ENCSR000BIU.USF1.WA01 224 bp overlap

ChIP WTC11 ENCFF699QGS 425 bp overlap

ChIP WTC11 ENCFF139JAW 371 bp overlap

ChIP H1 ENCFF524BTL 337 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 306 bp overlap

Motif DE_12h DE_12h-Yy1_MA0095.4 8 bp overlap

ZBTB33 1 dataset

ChIP WTC11 ENCFF048CFR 391 bp overlap

ZEB1 2 datasets

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

Motif ES_0h ES_0h-ZEB1_MA0103.4 6 bp overlap

Motif DE_12h DE_12h-ZIC1_MA0696.1 14 bp overlap

Motif DE_12h DE_12h-ZIC4_MA0751.2 14 bp overlap

Motif DE_12h DE_12h-ZIC5_MA1584.2 15 bp overlap

Motif ES_0h ES_0h-ZIM3_MA1709.2 11 bp overlap

ZNF143 1 dataset

ChIP WA09_heat-shock GSE105028.ZNF143.WA09_heat-shock 214 bp overlap

ZNF207 1 dataset

ChIP WA09 GSE118632.ZNF207.WA09 543 bp overlap

ZNF232 1 dataset

ChIP WTC11 ENCFF901BGD 460 bp overlap

ZNF263 1 dataset

ChIP K-562 ENCSR000EWN.ZNF263.K-562 172 bp overlap

ZNF274 1 dataset

ChIP HepG2 ENCFF155SWH 464 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 317 bp overlap

ZNF501 1 dataset

ChIP Hep-G2 ENCSR227PHM.ZNF501.Hep-G2 212 bp overlap

ZNF528 2 datasets

Motif DE_12h DE_12h-ZNF528_MA1597.1 17 bp overlap

Motif ES_0h ES_0h-ZNF528_MA1597.1 17 bp overlap

ZNF558 1 dataset

Motif DE_12h DE_12h-ZNF558_MA2335.1 29 bp overlap

ZNF652 2 datasets

Motif DE_12h DE_12h-ZNF652_MA1657.2 9 bp overlap

ChIP Hep-G2 ENCSR502GAX.ZNF652.Hep-G2 172 bp overlap

ZNF692 1 dataset

Motif ES_0h ES_0h-ZNF692_MA1986.2 8 bp overlap

ZNF75A 1 dataset

Motif DE_12h DE_12h-ZNF75A_MA2097.1 12 bp overlap

ZNF770 1 dataset

Motif ES_0h ES_0h-ZNF770_MA2099.1 8 bp overlap

ZNF816 2 datasets

Motif DE_12h DE_12h-ZNF816_MA1719.2 15 bp overlap

Motif ES_0h ES_0h-ZNF816_MA1719.2 15 bp overlap