RNASET2

ribonuclease T2 | FLJ10907, RNASE6PL, bA514O12.3

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

Biological processes 20 terms

RNA binding (GO:0003723)RNA catabolic process (GO:0006401)RNA catabolic process (GO:0006401)RNA catabolic process (GO:0006401)RNA endonuclease activity (GO:0004521)azurophil granule lumen (GO:0035578)endoplasmic reticulum lumen (GO:0005788)endoplasmic reticulum lumen (GO:0005788)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)innate immune response (GO:0045087)lysosomal lumen (GO:0043202)lysosomal lumen (GO:0043202)mitochondrial intermembrane space (GO:0005758)ribonuclease T2 activity (GO:0033897)ribonuclease T2 activity (GO:0033897)

Expression (TPM)

TFs regulating RNASET2 0 TFs

Transcription factors with Perturb-seq knockdown data for RNASET2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNASET2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RNASET2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNASET2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:166,862,101–166,863,325	93.9 kb	Distal (>10kb) Multiome	356
chr6:166,892,557–166,893,068	63.7 kb	Distal (>10kb) Multiome	11
chr6:166,949,735–166,950,229	6.6 kb	Proximal (<10kb) Multiome	130
chr6:166,951,435–166,951,645	4.9 kb	Proximal (<10kb)	263
chr6:166,955,870–166,957,689	20 bp	At TSS Multiome	930
chr6:166,997,827–166,999,955	42.7 kb	Distal (>10kb) Multiome	929
chr6:167,146,776–167,147,442	190.6 kb	Distal (>10kb) Multiome	130
chr6:167,163,221–167,164,006	207.1 kb	Distal (>10kb) Multiome	240
chr6:167,227,814–167,228,643	271.6 kb	Distal (>10kb) Multiome	140
chr6:167,244,852–167,245,449	288.6 kb	Distal (>10kb) Multiome	56

Genome Browser

Genomic view of the RNASET2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.