The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for MEF2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEF2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEF2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:99,402,101–99,402,755 | 163.6 kb | Distal (>10kb) Multiome | 160 | |
| chr15:99,447,371–99,447,978 | 118.4 kb | Distal (>10kb) Multiome | 143 | |
| chr15:99,564,843–99,566,939 | 85 bp | At TSS Multiome | 959 | |
| chr15:99,569,055–99,569,394 | 3.1 kb | Proximal (<10kb) | 40 | |
| chr15:99,574,541–99,574,792 | 8.6 kb | Proximal (<10kb) | 29 | |
| chr15:99,732,722–99,734,404 | 167.5 kb | Distal (>10kb) Multiome | 723 | |
| chr15:99,752,894–99,753,419 | 187.3 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the MEF2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.