This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for POU3F3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU3F3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU3F3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:104,844,412–104,845,692 | 8.4 kb | Proximal (<10kb) | 270 | |
| chr2:104,849,641–104,849,995 | 4.1 kb | Proximal (<10kb) | 147 | |
| chr2:104,852,203–104,854,491 | at TSS | At TSS | 475 | |
| chr2:104,854,617–104,857,215 | 503 bp | At TSS | 178 | |
| chr2:104,861,633–104,862,667 | 7.5 kb | Proximal (<10kb) | 214 | |
| chr2:104,863,519–104,864,305 | 9.4 kb | Proximal (<10kb) | 122 |
Genomic view of the POU3F3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.