This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EED. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EED upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EED, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:85,627,372–85,629,061 | 616.3 kb | Distal (>10kb) Multiome HiCAR | 826 | |
| chr11:85,663,762–85,665,466 | 579.7 kb | Distal (>10kb) Multiome HiCAR | 999 | |
| chr11:85,854,605–85,855,812 | 389.7 kb | Distal (>10kb) Multiome HiCAR | 948 | |
| chr11:86,052,796–86,053,429 | 191.7 kb | Distal (>10kb) Multiome | 169 | |
| chr11:86,068,044–86,070,093 | 175.5 kb | Distal (>10kb) Multiome | 1026 | |
| chr11:86,151,187–86,151,901 | 93.2 kb | Distal (>10kb) Multiome | 356 | |
| chr11:86,172,744–86,173,502 | 71.7 kb | Distal (>10kb) Multiome | 240 | |
| chr11:86,235,152–86,235,376 | 9.4 kb | Proximal (<10kb) | 73 | |
| chr11:86,244,135–86,246,099 | 232 bp | At TSS Multiome | 959 | |
| chr11:86,302,015–86,302,729 | 57.5 kb | Distal (>10kb) Multiome | 873 | |
| chr11:86,374,442–86,374,974 | 130.0 kb | Distal (>10kb) Multiome | 124 | |
| chr11:86,421,815–86,422,714 | 177.4 kb | Distal (>10kb) Multiome | 141 | |
| chr11:86,422,902–86,424,146 | 178.9 kb | Distal (>10kb) Multiome | 152 | |
| chr11:86,513,467–86,514,411 | 269.2 kb | Distal (>10kb) Multiome | 148 |
Genomic view of the EED locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.