The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
Transcription factors with Perturb-seq knockdown data for STAT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,107,497–42,108,335 | 280.6 kb | Distal (>10kb) Multiome | 357 | |
| chr17:42,120,858–42,121,715 | 267.2 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 265.8 kb | Distal (>10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 233.3 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,180,242–42,180,762 | 208.1 kb | Distal (>10kb) Multiome | 576 | |
| chr17:42,183,755–42,184,761 | 204.3 kb | Distal (>10kb) Multiome | 810 | |
| chr17:42,275,506–42,277,052 | 112.1 kb | Distal (>10kb) Multiome | 892 | |
| chr17:42,288,257–42,288,808 | 100.0 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 76.0 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 158 bp | At TSS Multiome | 1178 | |
| chr17:42,389,749–42,390,415 | 1.7 kb | Proximal (<10kb) Multiome | 95 | |
| chr17:42,422,618–42,423,513 | 34.7 kb | Distal (>10kb) Multiome | 765 | |
| chr17:42,531,503–42,532,256 | 143.5 kb | Distal (>10kb) Multiome | 571 | |
| chr17:42,535,863–42,536,855 | 147.8 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 160.0 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 166.3 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 173.6 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 178.6 kb | Distal (>10kb) Multiome | 902 | |
| chr17:42,577,421–42,578,281 | 189.3 kb | Distal (>10kb) Multiome | 884 | |
| chr17:42,578,382–42,578,892 | 190.2 kb | Distal (>10kb) Multiome | 477 | |
| chr17:42,608,764–42,610,335 | 221.0 kb | Distal (>10kb) Multiome | 909 | |
| chr17:42,658,938–42,659,852 | 270.8 kb | Distal (>10kb) Multiome | 734 | |
| chr17:42,669,472–42,671,112 | 282.3 kb | Distal (>10kb) Multiome | 230 | |
| chr17:42,673,584–42,674,462 | 285.5 kb | Distal (>10kb) Multiome | 296 | |
| chr17:42,674,847–42,675,579 | 286.7 kb | Distal (>10kb) Multiome | 194 | |
| chr17:42,676,055–42,678,790 | 288.6 kb | Distal (>10kb) Multiome | 1070 | |
| chr17:42,679,005–42,680,519 | 291.4 kb | Distal (>10kb) Multiome | 654 | |
| chr17:42,682,736–42,683,400 | 294.3 kb | Distal (>10kb) Multiome | 480 |
Genomic view of the STAT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.