USF2
upstream transcription factor 2, c-fos interacting | FIP, bHLHb12

This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

Biological processes 38 terms
DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)E-box binding (GO:0070888)E-box binding (GO:0070888)E-box binding (GO:0070888)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)bHLH transcription factor binding (GO:0043425)cellular response to glucose stimulus (GO:0071333)cellular response to glucose stimulus (GO:0071333)chromatin (GO:0000785)glucose mediated signaling pathway (GO:0010255)glucose mediated signaling pathway (GO:0010255)glucose mediated signaling pathway (GO:0010255)glucose mediated signaling pathway (GO:0010255)late viral transcription (GO:0019086)lipid homeostasis (GO:0055088)lipid homeostasis (GO:0055088)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)
Expression (TPM)
USF2 — as a Regulated Gene

TFs regulating USF2 0 TFs

Transcription factors with Perturb-seq knockdown data for USF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to USF2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:34,999,304–35,000,970 268.8 kb Distal (>10kb) Multiome 759
chr19:35,030,124–35,031,270 238.4 kb Distal (>10kb) Multiome 534
chr19:35,040,969–35,041,953 227.4 kb Distal (>10kb) Multiome 806
chr19:35,055,754–35,056,570 213.0 kb Distal (>10kb) Multiome 268
chr19:35,066,952–35,067,448 201.8 kb Distal (>10kb) Multiome 497
chr19:35,067,923–35,068,779 200.3 kb Distal (>10kb) Multiome 190
chr19:35,090,562–35,091,150 178.2 kb Distal (>10kb) Multiome 303
chr19:35,135,242–35,135,695 133.4 kb Distal (>10kb) Multiome 525
chr19:35,140,763–35,141,948 127.6 kb Distal (>10kb) Multiome 509
chr19:35,142,085–35,143,541 126.0 kb Distal (>10kb) Multiome 328
chr19:35,154,641–35,155,298 113.8 kb Distal (>10kb) Multiome 552
chr19:35,247,580–35,249,688 20.2 kb Distal (>10kb) Multiome 1088
chr19:35,266,852–35,270,128 739 bp At TSS Multiome 869
chr19:35,471,034–35,471,539 202.3 kb Distal (>10kb) Multiome 15
chr19:35,509,786–35,510,900 241.5 kb Distal (>10kb) Multiome 650
chr19:35,545,067–35,546,126 276.7 kb Distal (>10kb) Multiome 879
chr19:35,557,343–35,558,684 289.1 kb Distal (>10kb) Multiome 452

Genome Browser

Genomic view of the USF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:34,989,304 – 35,568,684
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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