This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for MORC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MORC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MORC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,694,739–30,695,381 | 274.0 kb | Distal (>10kb) Multiome | 278 | |
| chr22:30,802,592–30,803,363 | 165.8 kb | Distal (>10kb) Multiome | 898 | |
| chr22:30,968,406–30,969,906 | 349 bp | At TSS Multiome | 897 | |
| chr22:31,080,687–31,081,783 | 112.4 kb | Distal (>10kb) Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 116.3 kb | Distal (>10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 130.1 kb | Distal (>10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 136.3 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 138.9 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 158.8 kb | Distal (>10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 171.8 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 191.5 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 243.4 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the MORC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.