Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF692. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF692 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF692, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:247,007,420–247,008,623 | 1851.0 kb | Distal (>10kb) Multiome HiCAR | 629 | |
| chr1:247,089,108–247,090,336 | 1769.3 kb | Distal (>10kb) Multiome HiCAR | 197 | |
| chr1:247,330,646–247,333,480 | 1527.2 kb | Distal (>10kb) Multiome HiCAR | 839 | |
| chr1:247,356,823–247,358,156 | 1501.9 kb | Distal (>10kb) Multiome HiCAR | 296 | |
| chr1:247,376,539–247,377,867 | 1482.2 kb | Distal (>10kb) Multiome HiCAR | 164 | |
| chr1:247,448,083–247,448,740 | 1410.7 kb | Distal (>10kb) Multiome HiCAR | 246 | |
| chr1:248,825,287–248,827,024 | 33.0 kb | Distal (>10kb) Multiome | 866 | |
| chr1:248,837,447–248,839,602 | 20.9 kb | Distal (>10kb) Multiome | 979 | |
| chr1:248,847,039–248,848,710 | 11.4 kb | Distal (>10kb) Multiome HiCAR | 242 | |
| chr1:248,857,587–248,859,802 | 100 bp | At TSS Multiome | 984 | |
| chr1:248,862,776–248,863,977 | 4.3 kb | Proximal (<10kb) Multiome | 625 | |
| chr1:248,872,599–248,874,733 | 14.9 kb | Distal (>10kb) Multiome | 1099 | |
| chr1:248,905,646–248,907,461 | 47.3 kb | Distal (>10kb) Multiome | 1045 |
Genomic view of the ZNF692 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.