This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MEIS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEIS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEIS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:37,095,160–37,095,408 | 5.1 kb | Proximal (<10kb) | 97 | |
| chr15:37,097,156–37,097,549 | 3.0 kb | Proximal (<10kb) | 120 | |
| chr15:37,098,929–37,099,154 | 1.4 kb | Proximal (<10kb) | 271 | |
| chr15:37,100,244–37,101,061 | at TSS | At TSS | 660 | |
| chr15:37,101,201–37,102,291 | 671 bp | At TSS | 671 | |
| chr15:37,106,502–37,106,635 | 6.0 kb | Proximal (<10kb) | 101 | |
| chr15:37,106,747–37,106,943 | 6.2 kb | Proximal (<10kb) | 88 | |
| chr15:37,107,111–37,107,542 | 6.6 kb | Proximal (<10kb) | 70 | |
| chr15:37,110,814–37,111,049 | 9.5 kb | Proximal (<10kb) | 245 |
Genomic view of the MEIS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.