The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for BCL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:187,618,216–187,619,458 | 126.5 kb | Distal (>10kb) Multiome | 215 | |
| chr3:187,669,713–187,670,445 | 75.3 kb | Distal (>10kb) Multiome | 705 | |
| chr3:187,737,384–187,742,012 | 6.5 kb | Proximal (<10kb) Multiome | 974 | |
| chr3:187,742,125–187,742,331 | 3.1 kb | Proximal (<10kb) | 300 | |
| chr3:187,743,635–187,744,497 | 939 bp | At TSS | 309 | |
| chr3:187,744,634–187,746,096 | 186 bp | At TSS Multiome | 917 | |
| chr3:187,746,753–187,746,900 | 1.3 kb | Proximal (<10kb) | 73 | |
| chr3:187,748,044–187,748,506 | 2.6 kb | Proximal (<10kb) | 475 | |
| chr3:187,750,052–187,750,795 | 4.9 kb | Proximal (<10kb) Multiome | 613 | |
| chr3:187,989,510–187,990,198 | 244.5 kb | Distal (>10kb) Multiome HiCAR | 260 | |
| chr3:188,152,533–188,155,009 | 408.7 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr3:188,947,146–188,948,983 | 1202.5 kb | Distal (>10kb) Multiome HiCAR | 630 |
Genomic view of the BCL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.