This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for MYB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:134,902,167–134,902,866 | 278.9 kb | Distal (>10kb) Multiome | 91 | |
| chr6:135,054,252–135,055,511 | 126.4 kb | Distal (>10kb) Multiome | 968 | |
| chr6:135,173,644–135,174,012 | 7.3 kb | Proximal (<10kb) | 148 | |
| chr6:135,180,341–135,182,017 | 125 bp | At TSS Multiome | 668 | |
| chr6:135,182,179–135,184,155 | 1.7 kb | Proximal (<10kb) Multiome | 730 | |
| chr6:135,270,682–135,272,345 | 90.2 kb | Distal (>10kb) Multiome | 408 | |
| chr6:135,322,780–135,323,773 | 142.1 kb | Distal (>10kb) Multiome | 488 |
Genomic view of the MYB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.