IRF7
interferon regulatory factor 7

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]

Developmental clusters: GC2
Biological processes 62 terms
DNA binding (GO:0003677)DNA damage response (GO:0006974)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)MDA-5 signaling pathway (GO:0039530)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)chromatin (GO:0000785)cis-regulatory region sequence-specific DNA binding (GO:0000987)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)cytosol (GO:0005829)cytosol (GO:0005829)defense response to virus (GO:0051607)defense response to virus (GO:0051607)endosome membrane (GO:0010008)establishment of viral latency (GO:0019043)immune system process (GO:0002376)innate immune response (GO:0045087)innate immune response (GO:0045087)negative regulation of macrophage apoptotic process (GO:2000110)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of innate immune response (GO:0045089)positive regulation of interferon-alpha production (GO:0032727)positive regulation of interferon-alpha production (GO:0032727)positive regulation of interferon-beta production (GO:0032728)positive regulation of interferon-beta production (GO:0032728)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of type I interferon production (GO:0032481)positive regulation of type I interferon production (GO:0032481)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of MyD88-dependent toll-like receptor signaling pathway (GO:0034124)regulation of MyD88-dependent toll-like receptor signaling pathway (GO:0034124)regulation of MyD88-independent toll-like receptor signaling pathway (GO:0034127)regulation of MyD88-independent toll-like receptor signaling pathway (GO:0034127)regulation of adaptive immune response (GO:0002819)regulation of immune response (GO:0050776)regulation of monocyte differentiation (GO:0045655)regulation of transcription by RNA polymerase II (GO:0006357)regulation of type I interferon production (GO:0032479)response to virus (GO:0009615)sequence-specific double-stranded DNA binding (GO:1990837)signal transduction (GO:0007165)transcription cis-regulatory region binding (GO:0000976)type I interferon-mediated signaling pathway (GO:0060337)
Expression (TPM)
IRF7 — as a Regulated Gene

TFs regulating IRF7 0 TFs

Transcription factors with Perturb-seq knockdown data for IRF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IRF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to IRF7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IRF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:333,722–334,610 281.7 kb Distal (>10kb) Multiome 238
chr11:355,654–356,479 259.8 kb Distal (>10kb) Multiome 894
chr11:370,037–370,556 245.9 kb Distal (>10kb) Multiome 205
chr11:406,008–408,661 208.7 kb Distal (>10kb) Multiome 587
chr11:416,764–417,613 198.6 kb Distal (>10kb) Multiome 431
chr11:447,919–448,752 167.7 kb Distal (>10kb) Multiome 808
chr11:449,838–451,194 165.7 kb Distal (>10kb) Multiome 836
chr11:506,153–507,989 108.8 kb Distal (>10kb) Multiome 977
chr11:534,525–536,399 80.3 kb Distal (>10kb) Multiome 673
chr11:536,654–537,918 78.5 kb Distal (>10kb) Multiome 558
chr11:554,380–556,321 60.9 kb Distal (>10kb) Multiome 460
chr11:559,830–562,079 55.1 kb Distal (>10kb) Multiome 791
chr11:567,850–569,533 47.4 kb Distal (>10kb) Multiome 672
chr11:574,830–576,748 39.8 kb Distal (>10kb) Multiome 793
chr11:613,334–614,059 2.3 kb Proximal (<10kb) Multiome 215
chr11:615,262–616,320 100 bp At TSS Multiome 443
chr11:636,786–637,700 21.1 kb Distal (>10kb) Multiome 161
chr11:693,835–696,330 79.4 kb Distal (>10kb) Multiome 873
chr11:705,737–706,270 90.0 kb Distal (>10kb) Multiome 361
chr11:720,619–721,074 104.9 kb Distal (>10kb) Multiome 156
chr11:727,901–728,499 112.2 kb Distal (>10kb) Multiome 686
chr11:746,704–748,069 131.3 kb Distal (>10kb) Multiome 755
chr11:762,582–763,602 147.3 kb Distal (>10kb) Multiome HiCAR 326
chr11:776,216–778,328 161.4 kb Distal (>10kb) Multiome 770
chr11:783,385–783,909 167.7 kb Distal (>10kb) Multiome 278
chr11:797,112–798,675 182.3 kb Distal (>10kb) Multiome 697
chr11:804,241–805,812 189.3 kb Distal (>10kb) Multiome 725
chr11:808,894–810,402 193.7 kb Distal (>10kb) Multiome 976
chr11:818,369–820,592 203.5 kb Distal (>10kb) Multiome 749
chr11:826,980–828,116 211.6 kb Distal (>10kb) Multiome 662
chr11:828,933–831,262 214.3 kb Distal (>10kb) Multiome 491
chr11:832,323–833,565 216.8 kb Distal (>10kb) Multiome 562
chr11:842,034–843,556 226.7 kb Distal (>10kb) Multiome 794
chr11:843,773–845,220 228.5 kb Distal (>10kb) Multiome 664
chr11:849,082–850,270 233.7 kb Distal (>10kb) Multiome 229
chr11:910,337–911,591 295.0 kb Distal (>10kb) Multiome 754

Genome Browser

Genomic view of the IRF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:323,722 – 921,591
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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