CREB1
cAMP responsive element binding protein 1

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Member of: DE-3
Biological processes 106 terms
ATF4-CREB1 transcription factor complex (GO:1990589)ATF4-CREB1 transcription factor complex (GO:1990589)ATF4-CREB1 transcription factor complex (GO:1990589)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)Hsp70 protein binding (GO:0030544)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)arrestin family protein binding (GO:1990763)axon (GO:0030424)cAMP response element binding (GO:0035497)cAMP response element binding (GO:0035497)cAMP response element binding (GO:0035497)cAMP/PKA signal transduction (GO:0141156)cAMP/PKA signal transduction (GO:0141156)cell differentiation (GO:0030154)cellular response to fatty acid (GO:0071398)cellular response to forskolin (GO:1904322)cellular response to growth factor stimulus (GO:0071363)cellular response to insulin-like growth factor stimulus (GO:1990314)cellular response to nerve growth factor stimulus (GO:1990090)cellular response to platelet-derived growth factor stimulus (GO:0036120)cellular response to retinoic acid (GO:0071300)cellular response to retinoic acid (GO:0071300)cellular response to transforming growth factor beta stimulus (GO:0071560)chemotaxis to arachidonate (GO:0034670)chromatin (GO:0000785)chromatin (GO:0000785)circadian rhythm (GO:0007623)circadian rhythm (GO:0007623)enzyme binding (GO:0019899)euchromatin (GO:0000791)histone acetyltransferase binding (GO:0035035)identical protein binding (GO:0042802)mRNA transcription by RNA polymerase II (GO:0042789)memory (GO:0007613)mitochondrial matrix (GO:0005759)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of gene expression (GO:0010629)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of RNA polymerase II transcription preinitiation complex assembly (GO:0045899)positive regulation of apoptotic process (GO:0043065)positive regulation of fat cell differentiation (GO:0045600)positive regulation of fat cell differentiation (GO:0045600)positive regulation of gluconeogenesis (GO:0045722)positive regulation of lipid biosynthetic process (GO:0046889)positive regulation of lipid biosynthetic process (GO:0046889)positive regulation of long-term synaptic potentiation (GO:1900273)positive regulation of membrane depolarization (GO:1904181)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transforming growth factor beta3 production (GO:0032916)protein binding (GO:0005515)protein phosphorylation (GO:0006468)protein stabilization (GO:0050821)protein stabilization (GO:0050821)regulation of DNA-templated transcription (GO:0006355)regulation of apoptotic process (GO:0042981)regulation of fibroblast proliferation (GO:0048145)regulation of glial cell proliferation (GO:0060251)regulation of testosterone biosynthetic process (GO:2000224)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to L-glutamate (GO:1902065)response to activity (GO:0014823)response to cocaine (GO:0042220)response to dehydroepiandrosterone (GO:1903494)response to erythropoietin (GO:0036017)response to ethanol (GO:0045471)response to glucagon (GO:0033762)response to glucagon (GO:0033762)response to hypobaric hypoxia (GO:1990910)response to hypoxia (GO:0001666)response to morphine (GO:0043278)response to nicotine (GO:0035094)response to purine-containing compound (GO:0014074)response to xenobiotic stimulus (GO:0009410)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)signal transduction (GO:0007165)transcription cis-regulatory region binding (GO:0000976)transcription coactivator binding (GO:0001223)transcription regulator complex (GO:0005667)transforming growth factor beta receptor signaling pathway (GO:0007179)visual learning (GO:0008542)
Expression (TPM)
CREB1 — as a Regulated Gene

TFs regulating CREB1 0 TFs

Transcription factors with Perturb-seq knockdown data for CREB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CREB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CREB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CREB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:207,334,461–207,335,111 195.1 kb Distal (>10kb) Multiome 312
chr2:207,408,155–207,408,852 121.4 kb Distal (>10kb) Multiome 224
chr2:207,473,001–207,473,846 56.4 kb Distal (>10kb) Multiome 203
chr2:207,528,862–207,530,966 53 bp At TSS Multiome 969
chr2:207,624,610–207,626,664 96.1 kb Distal (>10kb) Multiome 1079
chr2:207,681,149–207,682,035 151.7 kb Distal (>10kb) Multiome 73
chr2:207,710,626–207,712,680 181.6 kb Distal (>10kb) Multiome 950
chr2:207,765,723–207,766,484 236.0 kb Distal (>10kb) Multiome 343
chr2:207,766,763–207,771,365 240.0 kb Distal (>10kb) Multiome 1084
chr2:207,796,609–207,797,752 267.1 kb Distal (>10kb) Multiome 545
chr2:207,800,773–207,801,891 271.5 kb Distal (>10kb) Multiome 374
chr2:207,810,355–207,811,806 281.2 kb Distal (>10kb) Multiome 482

Genome Browser

Genomic view of the CREB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:207,324,461 – 207,821,806
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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