Transcription factors with Perturb-seq knockdown data for ENSG00000227598. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227598 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227598, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:166,862,101–166,863,325 | 136.4 kb | Distal (>10kb) Multiome | 356 | |
| chr6:166,892,557–166,893,068 | 106.2 kb | Distal (>10kb) Multiome | 11 | |
| chr6:166,949,735–166,950,229 | 49.1 kb | Distal (>10kb) Multiome | 130 | |
| chr6:166,955,870–166,957,689 | 42.5 kb | Distal (>10kb) Multiome | 930 | |
| chr6:166,997,827–166,999,955 | 197 bp | At TSS Multiome | 929 | |
| chr6:167,146,776–167,147,442 | 148.1 kb | Distal (>10kb) Multiome | 130 | |
| chr6:167,163,221–167,164,006 | 164.6 kb | Distal (>10kb) Multiome | 240 | |
| chr6:167,227,814–167,228,643 | 229.1 kb | Distal (>10kb) Multiome | 140 | |
| chr6:167,244,852–167,245,449 | 246.1 kb | Distal (>10kb) Multiome | 56 | |
| chr6:167,272,179–167,273,192 | 273.7 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the ENSG00000227598 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.