This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for SUZ12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUZ12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUZ12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:31,842,394–31,842,839 | 94.3 kb | Distal (>10kb) Multiome | 401 | |
| chr17:31,858,598–31,859,915 | 77.7 kb | Distal (>10kb) Multiome | 554 | |
| chr17:31,901,289–31,902,051 | 35.2 kb | Distal (>10kb) Multiome | 697 | |
| chr17:31,916,726–31,917,673 | 19.8 kb | Distal (>10kb) Multiome | 134 | |
| chr17:31,936,506–31,937,522 | 24 bp | At TSS Multiome | 390 | |
| chr17:32,007,010–32,008,197 | 70.4 kb | Distal (>10kb) Multiome | 620 | |
| chr17:32,120,048–32,120,809 | 183.4 kb | Distal (>10kb) Multiome | 65 | |
| chr17:32,127,304–32,127,868 | 190.6 kb | Distal (>10kb) Multiome | 369 | |
| chr17:32,142,020–32,143,266 | 205.4 kb | Distal (>10kb) Multiome | 737 |
Genomic view of the SUZ12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.