This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for JARID2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JARID2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JARID2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:15,021,725–15,022,783 | 223.9 kb | Distal (>10kb) Multiome | 216 | |
| chr6:15,038,269–15,038,858 | 207.5 kb | Distal (>10kb) Multiome | 88 | |
| chr6:15,243,089–15,243,613 | 2.7 kb | Proximal (<10kb) Multiome | 93 | |
| chr6:15,244,355–15,244,565 | 1.5 kb | Proximal (<10kb) | 199 | |
| chr6:15,244,671–15,246,133 | 400 bp | At TSS Multiome | 1018 | |
| chr6:15,247,856–15,249,483 | 2.6 kb | Proximal (<10kb) Multiome | 825 | |
| chr6:15,268,231–15,269,003 | 22.6 kb | Distal (>10kb) Multiome | 177 | |
| chr6:15,409,286–15,410,423 | 163.6 kb | Distal (>10kb) Multiome | 247 | |
| chr6:15,434,237–15,434,856 | 188.5 kb | Distal (>10kb) Multiome | 263 | |
| chr6:15,460,916–15,461,553 | 215.2 kb | Distal (>10kb) Multiome | 161 |
Genomic view of the JARID2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.