POU2F2

POU class 2 homeobox 2 | OCT2, OTF2

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Biological processes 25 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulator complex (GO:0090575)cellular response to virus (GO:0098586)chromatin (GO:0000785)cytoplasm (GO:0005737)humoral immune response (GO:0006959)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of interleukin-6 production (GO:0032755)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating POU2F2 0 TFs

Transcription factors with Perturb-seq knockdown data for POU2F2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU2F2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POU2F2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU2F2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:41,859,455–41,860,753	272.6 kb	Distal (>10kb) Multiome	1018
chr19:41,883,883–41,884,651	248.2 kb	Distal (>10kb) Multiome	917
chr19:41,887,651–41,888,254	244.5 kb	Distal (>10kb) Multiome	553
chr19:41,927,700–41,928,620	204.3 kb	Distal (>10kb) Multiome	277
chr19:41,930,462–41,931,200	201.5 kb	Distal (>10kb) Multiome	147
chr19:41,957,648–41,959,799	173.9 kb	Distal (>10kb) Multiome	839
chr19:41,993,779–41,994,412	138.3 kb	Distal (>10kb) Multiome	360
chr19:41,998,577–41,999,349	133.6 kb	Distal (>10kb) Multiome	292
chr19:42,075,557–42,076,657	56.4 kb	Distal (>10kb) Multiome	846
chr19:42,095,735–42,096,278	36.4 kb	Distal (>10kb) Multiome	107
chr19:42,132,949–42,133,545	816 bp	At TSS Multiome	447
chr19:42,140,233–42,140,426	7.8 kb	Proximal (<10kb)	405
chr19:42,176,787–42,177,398	44.7 kb	Distal (>10kb) Multiome	381
chr19:42,216,521–42,218,719	85.2 kb	Distal (>10kb) Multiome	841
chr19:42,219,693–42,220,678	87.8 kb	Distal (>10kb) Multiome	735
chr19:42,241,985–42,243,820	110.5 kb	Distal (>10kb) Multiome	891
chr19:42,244,086–42,245,258	112.4 kb	Distal (>10kb) Multiome	768
chr19:42,253,030–42,256,178	121.4 kb	Distal (>10kb) Multiome	900
chr19:42,267,812–42,269,463	136.4 kb	Distal (>10kb) Multiome	887
chr19:42,279,620–42,280,909	147.6 kb	Distal (>10kb) Multiome	818
chr19:42,283,173–42,285,280	151.6 kb	Distal (>10kb) Multiome	739
chr19:42,301,842–42,303,114	170.1 kb	Distal (>10kb) Multiome	858
chr19:42,313,206–42,313,892	181.1 kb	Distal (>10kb) Multiome	515
chr19:42,323,530–42,326,402	193.0 kb	Distal (>10kb) Multiome HiCAR	833
chr19:42,386,878–42,387,621	254.8 kb	Distal (>10kb) Multiome	602
chr19:42,396,430–42,397,663	264.5 kb	Distal (>10kb) Multiome	585
chr19:42,401,221–42,402,278	269.3 kb	Distal (>10kb) Multiome	475
chr19:42,422,934–42,424,367	291.3 kb	Distal (>10kb) Multiome	439

Genome Browser

Genomic view of the POU2F2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.