The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021]
Transcription factors with Perturb-seq knockdown data for TRIM25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:56,678,153–56,679,472 | 235.1 kb | Distal (>10kb) Multiome | 301 | |
| chr17:56,708,321–56,709,261 | 205.2 kb | Distal (>10kb) Multiome | 92 | |
| chr17:56,779,885–56,780,781 | 133.7 kb | Distal (>10kb) Multiome | 694 | |
| chr17:56,833,054–56,835,255 | 80.1 kb | Distal (>10kb) Multiome | 970 | |
| chr17:56,913,307–56,914,659 | at TSS | At TSS Multiome | 1051 | |
| chr17:56,960,529–56,961,254 | 46.8 kb | Distal (>10kb) Multiome | 955 | |
| chr17:56,977,708–56,978,393 | 64.0 kb | Distal (>10kb) Multiome | 552 | |
| chr17:57,084,539–57,086,640 | 171.1 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:57,099,741–57,100,357 | 186.0 kb | Distal (>10kb) Multiome | 119 |
Genomic view of the TRIM25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.