DE-8

Supermodule 345 genes

Ciliary and flagellar structure genes

This module comprises 360 genes including VWF, HTT, MALAT1, MTR, and NEAT1, with enrichment for cilium, sperm flagellum, and motile cilium components. No transcription factor knockdown data are available for this module.

Notable genes: VWF HTT MALAT1 MTR NEAT1 TET2 DISC1 PDCD4 Top TFs: AATF ADNP AEBP2 AFF1 AFF4

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (18)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-8.1	41	HTT OGT RNF213 PFKFB3 CDKL5
DE-8.2	24	ANKRD26 TSGA10 STX8 HHAT FGGY
DE-8.3	22	MALAT1 NEAT1 AKT3 FAF1 SEMA5A
DE-8.4	20	GLI2 HIP1 WNT5B USP13 GRIK3
DE-8.5	18	CASC9 RBM47 USP9Y CAMKMT KIAA1217
DE-8.6	18	TET2 IFT88 DNAJC13 UBR1 COG6
DE-8.7	16	CC2D2A TPT1-AS1 LINC00174 ARMC9 ASB3
DE-8.8	15	CLOCK SIN3A MICU1 VPS13A ELOVL6
DE-8.9	15	RPS6KA5 LNPEP EFHC1 EVC2 STRADA
DE-8.10	14	C1RL NME7 PAX8-AS1 RSRP1 TTC14
DE-8.11	13	ROBO1 MEF2A EYA1 GLCCI1 RASAL2
DE-8.12	13	TRPC1 NORAD PIK3C3 NRIP1 HMBOX1
DE-8.13	12	TP53BP1 LGR5 PDE4D EPHA4 SLIT3
DE-8.14	11	VWF DISC1 PCAT1 ANO2 IGSF11
DE-8.15	11	PDCD4 JAK1 RICTOR ATP2B4 CREBRF
DE-8.16	10	SGIP1 FSIP2 ZNF33A ENSG00000214955 RAB33B-AS1
DE-8.17	10	PI4KA PXDN CELSR1 SH3PXD2B ADCY7
DE-8.18	10	SETDB1 SUFU ACAD10 MTFR1 CTPS2

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).