Predicted to be involved in cilium assembly and positive regulation of smoothened signaling pathway. Located in centriole and ciliary basal body. Implicated in Joubert syndrome 30. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARMC9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMC9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMC9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:230,902,219–230,902,930 | 296.0 kb | Distal (>10kb) Multiome | 248 | |
| chr2:230,987,027–230,987,549 | 211.2 kb | Distal (>10kb) Multiome | 571 | |
| chr2:231,037,208–231,038,499 | 160.8 kb | Distal (>10kb) Multiome | 457 | |
| chr2:231,052,341–231,053,359 | 145.7 kb | Distal (>10kb) Multiome | 810 | |
| chr2:231,056,470–231,057,439 | 141.9 kb | Distal (>10kb) Multiome | 821 | |
| chr2:231,189,962–231,191,188 | 7.9 kb | Proximal (<10kb) Multiome | 358 | |
| chr2:231,192,512–231,192,939 | 5.7 kb | Proximal (<10kb) | 207 | |
| chr2:231,198,151–231,199,150 | 5 bp | At TSS Multiome | 760 | |
| chr2:231,297,093–231,297,547 | 98.6 kb | Distal (>10kb) Multiome | 344 | |
| chr2:231,337,851–231,338,311 | 139.4 kb | Distal (>10kb) Multiome | 58 | |
| chr2:231,370,064–231,371,397 | 172.2 kb | Distal (>10kb) Multiome | 214 | |
| chr2:231,375,406–231,377,370 | 177.9 kb | Distal (>10kb) Multiome | 232 | |
| chr2:231,394,766–231,396,655 | 197.0 kb | Distal (>10kb) Multiome | 339 | |
| chr2:231,410,617–231,411,062 | 212.1 kb | Distal (>10kb) Multiome | 150 | |
| chr2:231,411,845–231,413,014 | 213.7 kb | Distal (>10kb) Multiome | 691 | |
| chr2:231,463,695–231,465,687 | 266.0 kb | Distal (>10kb) Multiome | 1126 | |
| chr2:231,482,645–231,483,215 | 284.3 kb | Distal (>10kb) Multiome | 450 | |
| chr2:231,483,468–231,484,163 | 285.3 kb | Distal (>10kb) Multiome | 197 |
Genomic view of the ARMC9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.