DE-8 ›

DE-8.12

Submodule 13 genes

Calcium signaling and autophagy regulators

This 13-gene module includes TRPC1, NORAD, PIK3C3, NRIP1, and HMBOX1, with top enriched terms related to calcium ion transport, autophagy, and intracellular signaling. Knockdown of SOX17, FOXA2, and GATA4 activates this module. Knockdown of EOMES represses this module.

Key terms: positive regulation of protein lipidation positive regulation of lipoprotein metabolic process regulation of protein lipidation regulation of lipoprotein metabolic process Notable genes: TRPC1 NORAD PIK3C3 NRIP1 HMBOX1 HEPH IGSF1 RAB3GAP2

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (13)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact