This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for MTFR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTFR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTFR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:65,360,884–65,361,786 | 283.4 kb | Distal (>10kb) Multiome | 114 | |
| chr8:65,560,267–65,560,834 | 84.1 kb | Distal (>10kb) Multiome | 210 | |
| chr8:65,633,786–65,634,726 | 10.5 kb | Distal (>10kb) Multiome | 837 | |
| chr8:65,636,619–65,636,903 | 7.8 kb | Proximal (<10kb) | 138 | |
| chr8:65,643,517–65,645,623 | 4 bp | At TSS Multiome | 852 | |
| chr8:65,840,608–65,843,127 | 197.6 kb | Distal (>10kb) Multiome | 1129 |
Genomic view of the MTFR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.