This 18-gene module includes TET2, IFT88, DNAJC13, UBR1, and COG6, with top enriched terms related to vesicular transport, protein localization, and intracellular trafficking. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN, NANOG, and POU5F1 repress it. The module likely supports endoderm specification through regulated cargo movement and protein quality control mechanisms.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.