This gene encodes a member of the Dnaj protein family whose members act as co-chaperones of a partner heat-shock protein by binding to the latter and stimulating ATP hydrolysis. The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis. It may also be involved in post-endocytic transport mechanisms via its associations with other proteins, including the sorting nexin SNX1. Mutations in this gene are associated with Parkinson's disease. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for DNAJC13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:132,283,581–132,286,246 | 131.8 kb | Distal (>10kb) Multiome | 334 | |
| chr3:132,382,239–132,383,246 | 34.9 kb | Distal (>10kb) Multiome | 203 | |
| chr3:132,414,895–132,415,139 | 2.4 kb | Proximal (<10kb) | 16 | |
| chr3:132,415,264–132,415,388 | 2.1 kb | Proximal (<10kb) | 6 | |
| chr3:132,416,687–132,418,425 | 117 bp | At TSS Multiome | 733 | |
| chr3:132,644,811–132,645,749 | 227.8 kb | Distal (>10kb) Multiome | 191 | |
| chr3:132,659,118–132,660,967 | 242.9 kb | Distal (>10kb) Multiome | 872 |
Genomic view of the DNAJC13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.